Senior Research Associate
Department of Radiology, University of Cambridge School of Clinical Medicine.
Contact: Email: M McLean Tel.: + 44 (0)1223 256255
Profile
Mary McLean received a Bachelor of Science in Biochemistry from Pennsylvania State University in 1989, summa cum laude, and a PhD in Biochemistry from University of Cambridge in 1994 on the topic of 13C-NMR tracer studies of brain metabolism. She worked as a postdoc in cancer imaging and spectroscopy at St George’s Hospital Medical School, and in flow imaging at Imperial College London, followed by a 10-year stint as a Senior RA and Honorary Lecturer in Physics at UCL, where she was the principal physicist for MR spectroscopy in epilepsy and multiple sclerosis. During her last few years there she was also an honorary senior lecturer at the Institute of Psychiatry, KCL, collaborating on studies of neuropsychiatric disorders.
She returned to Cambridge in 2007 as a staff scientist in the newly-built Cancer Research UK Cambridge Institute, working with John Griffiths on a wide range of projects in cancer MR spectroscopy and imaging. Her recent focus has been molecular imaging of hyperpolarized 13C, deuterium, and sodium, working with PIs Ferdia Gallagher, Fiona Gilbert, Tomasz Matys and Tristan Barrett, among others.
Mary is a past member of the Executive Committee of the British Chapter of ISMRM and the Founding Editor of “Positive Spin”, the newsletter of the British MR research community. Archived issues can be found at: https://www.ismrm.org/chapters/british-chapter.
Last 5 Publications:
2789237
mclean
items
1
apa
5
date
desc
5913
https://radiology.medschl.cam.ac.uk/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-692715d66de752b43a0d1f8faaed85d1%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22Y4TBB6AG%22%2C%22library%22%3A%7B%22id%22%3A2789237%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Woitek%20et%20al.%22%2C%22parsedDate%22%3A%222023-04-05%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EWoitek%2C%20R.%2C%20McLean%2C%20M.%20A.%2C%20Ursprung%2C%20S.%2C%20Rueda%2C%20O.%20M.%2C%20Manzano%20Garcia%2C%20R.%2C%20Locke%2C%20M.%20J.%2C%20Beer%2C%20L.%2C%20Baxter%2C%20G.%2C%20Rundo%2C%20L.%2C%20Provenzano%2C%20E.%2C%20Kaggie%2C%20J.%2C%20Patterson%2C%20A.%2C%20Frary%2C%20A.%2C%20Field-Rayner%2C%20J.%2C%20Papalouka%2C%20V.%2C%20Kane%2C%20J.%2C%20Benjamin%2C%20A.%20J.%20V.%2C%20Gill%2C%20A.%20B.%2C%20Priest%2C%20A.%20N.%2C%20%26%23x2026%3B%20Gallagher%2C%20F.%20A.%20%282023%29.%20Supplementary%20Materials%20from%20Hyperpolarized%20Carbon-13%20MRI%20for%20Early%20Response%20Assessment%20of%20Neoadjuvant%20Chemotherapy%20in%20Breast%20Cancer%20Patients.%20%3Ci%3EAmerican%20Association%20for%20Cancer%20Research%20%28AACR%29%3C%5C%2Fi%3E.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1158%5C%2F0008-5472.22561915%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1158%5C%2F0008-5472.22561915%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Supplementary%20Materials%20from%20Hyperpolarized%20Carbon-13%20MRI%20for%20Early%20Response%20Assessment%20of%20Neoadjuvant%20Chemotherapy%20in%20Breast%20Cancer%20Patients%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Woitek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.A.%22%2C%22lastName%22%3A%22McLean%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Ursprung%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22O.M.%22%2C%22lastName%22%3A%22Rueda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Manzano%20Garcia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.J.%22%2C%22lastName%22%3A%22Locke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Beer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Baxter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Rundo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Provenzano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Kaggie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Patterson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Frary%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Field-Rayner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V.%22%2C%22lastName%22%3A%22Papalouka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Kane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.J.V.%22%2C%22lastName%22%3A%22Benjamin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.B.%22%2C%22lastName%22%3A%22Gill%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.N.%22%2C%22lastName%22%3A%22Priest%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.Y.%22%2C%22lastName%22%3A%22Lewis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Russell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Grimmer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22White%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Latimer-Bowman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22I.%22%2C%22lastName%22%3A%22Patterson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Schiller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Carmo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Slough%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T.%22%2C%22lastName%22%3A%22Lanz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Wason%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.F.%22%2C%22lastName%22%3A%22Schulte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S-F.%22%2C%22lastName%22%3A%22Chin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.J.%22%2C%22lastName%22%3A%22Graves%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.J.%22%2C%22lastName%22%3A%22Gilbert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.E.%22%2C%22lastName%22%3A%22Abraham%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Caldas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.M.%22%2C%22lastName%22%3A%22Brindle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Sala%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.A.%22%2C%22lastName%22%3A%22Gallagher%22%7D%5D%2C%22abstractNote%22%3A%22%3Cp%3ESupplementary%20Materials%20%28clean%29%3C%5C%2Fp%3E%22%2C%22date%22%3A%222023-04-05%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1158%5C%2F0008-5472.22561915%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%224956CJHC%22%5D%2C%22dateModified%22%3A%222023-05-09T12%3A28%3A25Z%22%7D%7D%2C%7B%22key%22%3A%229RMGBL8T%22%2C%22library%22%3A%7B%22id%22%3A2789237%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Woitek%20et%20al.%22%2C%22parsedDate%22%3A%222023-04-05%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EWoitek%2C%20R.%2C%20McLean%2C%20M.%20A.%2C%20Ursprung%2C%20S.%2C%20Rueda%2C%20O.%20M.%2C%20Manzano%20Garcia%2C%20R.%2C%20Locke%2C%20M.%20J.%2C%20Beer%2C%20L.%2C%20Baxter%2C%20G.%2C%20Rundo%2C%20L.%2C%20Provenzano%2C%20E.%2C%20Kaggie%2C%20J.%2C%20Patterson%2C%20A.%2C%20Frary%2C%20A.%2C%20Field-Rayner%2C%20J.%2C%20Papalouka%2C%20V.%2C%20Kane%2C%20J.%2C%20Benjamin%2C%20A.%20J.%20V.%2C%20Gill%2C%20A.%20B.%2C%20Priest%2C%20A.%20N.%2C%20%26%23x2026%3B%20Gallagher%2C%20F.%20A.%20%282023%29.%20Data%20from%20Hyperpolarized%20Carbon-13%20MRI%20for%20Early%20Response%20Assessment%20of%20Neoadjuvant%20Chemotherapy%20in%20Breast%20Cancer%20Patients.%20%3Ci%3EAmerican%20Association%20for%20Cancer%20Research%20%28AACR%29%3C%5C%2Fi%3E.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1158%5C%2F0008-5472.c.6565186%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1158%5C%2F0008-5472.c.6565186%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Data%20from%20Hyperpolarized%20Carbon-13%20MRI%20for%20Early%20Response%20Assessment%20of%20Neoadjuvant%20Chemotherapy%20in%20Breast%20Cancer%20Patients%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Woitek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.A.%22%2C%22lastName%22%3A%22McLean%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Ursprung%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22O.M.%22%2C%22lastName%22%3A%22Rueda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Manzano%20Garcia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.J.%22%2C%22lastName%22%3A%22Locke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Beer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Baxter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Rundo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Provenzano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Kaggie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Patterson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Frary%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Field-Rayner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V.%22%2C%22lastName%22%3A%22Papalouka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Kane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.J.V.%22%2C%22lastName%22%3A%22Benjamin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.B.%22%2C%22lastName%22%3A%22Gill%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.N.%22%2C%22lastName%22%3A%22Priest%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.Y.%22%2C%22lastName%22%3A%22Lewis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Russell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Grimmer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22White%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Latimer-Bowman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22I.%22%2C%22lastName%22%3A%22Patterson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Schiller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Carmo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Slough%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T.%22%2C%22lastName%22%3A%22Lanz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Wason%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.F.%22%2C%22lastName%22%3A%22Schulte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S-F.%22%2C%22lastName%22%3A%22Chin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.J.%22%2C%22lastName%22%3A%22Graves%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.J.%22%2C%22lastName%22%3A%22Gilbert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.E.%22%2C%22lastName%22%3A%22Abraham%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Caldas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.M.%22%2C%22lastName%22%3A%22Brindle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Sala%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.A.%22%2C%22lastName%22%3A%22Gallagher%22%7D%5D%2C%22abstractNote%22%3A%22%3Cdiv%3EAbstract%3Cp%3EHyperpolarized%20%3Csup%3E13%3C%5C%2Fsup%3EC-MRI%20is%20an%20emerging%20tool%20for%20probing%20tissue%20metabolism%20by%20measuring%20%3Csup%3E13%3C%5C%2Fsup%3EC-label%20exchange%20between%20intravenously%20injected%20hyperpolarized%20%5B1%5Cu2013%3Csup%3E13%3C%5C%2Fsup%3EC%5Dpyruvate%20and%20endogenous%20tissue%20lactate.%20Here%2C%20we%20demonstrate%20that%20hyperpolarized%20%3Csup%3E13%3C%5C%2Fsup%3EC-MRI%20can%20be%20used%20to%20detect%20early%20response%20to%20neoadjuvant%20therapy%20in%20breast%20cancer.%20Seven%20patients%20underwent%20multiparametric%20%3Csup%3E1%3C%5C%2Fsup%3EH-MRI%20and%20hyperpolarized%20%3Csup%3E13%3C%5C%2Fsup%3EC-MRI%20before%20and%207%5Cu201311%20days%20after%20commencing%20treatment.%20An%20increase%20in%20the%20lactate-to-pyruvate%20ratio%20of%20approximately%2020%25%20identified%20three%20patients%20who%2C%20following%205%5Cu20136%20cycles%20of%20treatment%2C%20showed%20pathological%20complete%20response.%20This%20ratio%20correlated%20with%20gene%20expression%20of%20the%20pyruvate%20transporter%20%3Ci%3EMCT1%3C%5C%2Fi%3E%20and%20lactate%20dehydrogenase%20A%20%28%3Ci%3ELDHA%3C%5C%2Fi%3E%29%2C%20the%20enzyme%20catalyzing%20label%20exchange%20between%20pyruvate%20and%20lactate.%20Analysis%20of%20approximately%202%2C000%20breast%20tumors%20showed%20that%20overexpression%20of%20%3Ci%3ELDHA%3C%5C%2Fi%3E%20and%20the%20hypoxia%20marker%20%3Ci%3ECAIX%3C%5C%2Fi%3E%20was%20associated%20with%20reduced%20relapse-free%20and%20overall%20survival.%20Hyperpolarized%20%3Csup%3E13%3C%5C%2Fsup%3EC-MRI%20represents%20a%20promising%20method%20for%20monitoring%20very%20early%20treatment%20response%20in%20breast%20cancer%20and%20has%20demonstrated%20prognostic%20potential.%3C%5C%2Fp%3ESignificance%3A%3Cp%3EHyperpolarized%20carbon-13%20MRI%20allows%20response%20assessment%20in%20patients%20with%20breast%20cancer%20after%207%5Cu201311%20days%20of%20neoadjuvant%20chemotherapy%20and%20outperformed%20state-of-the-art%20and%20research%20quantitative%20proton%20MRI%20techniques.%3C%5C%2Fp%3E%3C%5C%2Fdiv%3E%22%2C%22date%22%3A%222023-04-05%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1158%5C%2F0008-5472.c.6565186%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%224956CJHC%22%5D%2C%22dateModified%22%3A%222023-05-09T12%3A28%3A30Z%22%7D%7D%2C%7B%22key%22%3A%222FJ5SB3U%22%2C%22library%22%3A%7B%22id%22%3A2789237%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zaccagna%20et%20al.%22%2C%22parsedDate%22%3A%222022-07%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EZaccagna%2C%20F.%2C%20McLean%2C%20M.%20A.%2C%20Grist%2C%20J.%20T.%2C%20Kaggie%2C%20J.%2C%20Mair%2C%20R.%2C%20Riemer%2C%20F.%2C%20Woitek%2C%20R.%2C%20Gill%2C%20A.%20B.%2C%20Deen%2C%20S.%2C%20Daniels%2C%20C.%20J.%2C%20Ursprung%2C%20S.%2C%20Schulte%2C%20R.%20F.%2C%20Allinson%2C%20K.%2C%20Chhabra%2C%20A.%2C%20Laurent%2C%20M.-C.%2C%20Locke%2C%20M.%2C%20Frary%2C%20A.%2C%20Hilborne%2C%20S.%2C%20Patterson%2C%20I.%2C%20%26%23x2026%3B%20Gallagher%2C%20F.%20A.%20%282022%29.%20Imaging%20Glioblastoma%20Metabolism%20by%20Using%20Hyperpolarized%20%5B1-13C%5DPyruvate%20Demonstrates%20Heterogeneity%20in%20Lactate%20Labeling%3A%20A%20Proof%20of%20Principle%20Study.%20%3Ci%3ERadiol%20Imaging%20Cancer%3C%5C%2Fi%3E%2C%20%3Ci%3E4%3C%5C%2Fi%3E%284%29%2C%20e210076.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1148%5C%2Frycan.210076%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1148%5C%2Frycan.210076%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Imaging%20Glioblastoma%20Metabolism%20by%20Using%20Hyperpolarized%20%5B1-13C%5DPyruvate%20Demonstrates%20Heterogeneity%20in%20Lactate%20Labeling%3A%20A%20Proof%20of%20Principle%20Study.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.%22%2C%22lastName%22%3A%22Zaccagna%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.A.%22%2C%22lastName%22%3A%22McLean%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.T.%22%2C%22lastName%22%3A%22Grist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Kaggie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Mair%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.%22%2C%22lastName%22%3A%22Riemer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Woitek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.B.%22%2C%22lastName%22%3A%22Gill%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Deen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.J.%22%2C%22lastName%22%3A%22Daniels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Ursprung%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.F.%22%2C%22lastName%22%3A%22Schulte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%22%2C%22lastName%22%3A%22Allinson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Chhabra%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M-C.%22%2C%22lastName%22%3A%22Laurent%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Locke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Frary%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Hilborne%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22I.%22%2C%22lastName%22%3A%22Patterson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.D.%22%2C%22lastName%22%3A%22Carmo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Slough%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22I.%22%2C%22lastName%22%3A%22Wilkinson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Basu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Wason%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.H.%22%2C%22lastName%22%3A%22Gillard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T.%22%2C%22lastName%22%3A%22Matys%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Watts%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.J.%22%2C%22lastName%22%3A%22Price%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T.%22%2C%22lastName%22%3A%22Santarius%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.J.%22%2C%22lastName%22%3A%22Graves%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Jefferies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.M.%22%2C%22lastName%22%3A%22Brindle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.A.%22%2C%22lastName%22%3A%22Gallagher%22%7D%5D%2C%22abstractNote%22%3A%22Purpose%20To%20evaluate%20glioblastoma%20%28GBM%29%20metabolism%20by%20using%20hyperpolarized%20carbon%2013%20%2813C%29%20MRI%20to%20monitor%20the%20exchange%20of%20the%20hyperpolarized%2013C%20label%20between%20injected%20%5B1-13C%5Dpyruvate%20and%20tumor%20lactate%20and%20bicarbonate.%20Materials%20and%20Methods%20In%20this%20prospective%20study%2C%20seven%20treatment-naive%20patients%20%28age%20%5Bmean%20%5Cu00b1%20SD%5D%2C%2060%20years%20%5Cu00b1%2011%3B%20five%20men%29%20with%20GBM%20were%20imaged%20at%203%20T%20by%20using%20a%20dual-tuned%2013C-hydrogen%201%20head%20coil.%20Hyperpolarized%20%5B1-13C%5Dpyruvate%20was%20injected%2C%20and%20signal%20was%20acquired%20by%20using%20a%20dynamic%20MRI%20spiral%20sequence.%20Metabolism%20was%20assessed%20within%20the%20tumor%2C%20in%20the%20normal-appearing%20brain%20parenchyma%20%28NABP%29%2C%20and%20in%20healthy%20volunteers%20by%20using%20paired%20or%20unpaired%20t%20tests%20and%20a%20Wilcoxon%20signed%20rank%20test.%20The%20Spearman%20%5Cu03c1%20correlation%20coefficient%20was%20used%20to%20correlate%20metabolite%20labeling%20with%20lactate%20dehydrogenase%20A%20%28LDH-A%29%20expression%20and%20some%20immunohistochemical%20markers.%20The%20Benjamini-Hochberg%20procedure%20was%20used%20to%20correct%20for%20multiple%20comparisons.%20Results%20The%20bicarbonate-to-pyruvate%20%28BP%29%20ratio%20was%20lower%20in%20the%20tumor%20than%20in%20the%20contralateral%20NABP%20%28P%20%3C%20.01%29.%20The%20tumor%20lactate-to-pyruvate%20%28LP%29%20ratio%20was%20not%20different%20from%20that%20in%20the%20NABP%20%28P%20%3D%20.38%29.%20The%20LP%20and%20BP%20ratios%20in%20the%20NABP%20were%20higher%20than%20those%20observed%20previously%20in%20healthy%20volunteers%20%28P%20%3C%20.05%29.%20Tumor%20lactate%20and%20bicarbonate%20signal%20intensities%20were%20strongly%20correlated%20with%20the%20pyruvate%20signal%20intensity%20%28%5Cu03c1%20%3D%200.92%2C%20P%20%3C%20.001%2C%20and%20%5Cu03c1%20%3D%200.66%2C%20P%20%3C%20.001%2C%20respectively%29%2C%20and%20the%20LP%20ratio%20was%20weakly%20correlated%20with%20LDH-A%20expression%20in%20biopsy%20samples%20%28%5Cu03c1%20%3D%200.43%2C%20P%20%3D%20.04%29.%20Conclusion%20Hyperpolarized%2013C%20MRI%20demonstrated%20variation%20in%20lactate%20labeling%20in%20GBM%2C%20both%20within%20and%20between%20tumors.%20In%20contrast%2C%20bicarbonate%20labeling%20was%20consistently%20lower%20in%20tumors%20than%20in%20the%20surrounding%20NABP.%20Keywords%3A%20Hyperpolarized%2013C%20MRI%2C%20Glioblastoma%2C%20Metabolism%2C%20Cancer%2C%20MRI%2C%20Neuro-oncology%20Supplemental%20material%20is%20available%20for%20this%20article.%20Published%20under%20a%20CC%20BY%204.0%20license.%22%2C%22date%22%3A%222022-07%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1148%5C%2Frycan.210076%22%2C%22ISSN%22%3A%222638-616X%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpubmed%5C%2F35838532%22%2C%22collections%22%3A%5B%224956CJHC%22%5D%2C%22dateModified%22%3A%222023-01-09T13%3A07%3A46Z%22%7D%7D%2C%7B%22key%22%3A%22QIHNIJEZ%22%2C%22library%22%3A%7B%22id%22%3A2789237%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Sushentsev%20et%20al.%22%2C%22parsedDate%22%3A%222022-06-22%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ESushentsev%2C%20N.%2C%20McLean%2C%20M.%20A.%2C%20Warren%2C%20A.%20Y.%2C%20Brodie%2C%20C.%2C%20Jones%2C%20J.%2C%20Gallagher%2C%20F.%20A.%2C%20%26amp%3B%20Barrett%2C%20T.%20%282022%29.%20The%20potential%20of%20hyperpolarised%2013C-MRI%20to%20target%20glycolytic%20tumour%20core%20in%20prostate%20cancer.%20%3Ci%3EEur%20Radiol%3C%5C%2Fi%3E.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00330-022-08929-7%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00330-022-08929-7%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20potential%20of%20hyperpolarised%2013C-MRI%20to%20target%20glycolytic%20tumour%20core%20in%20prostate%20cancer.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Sushentsev%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.A.%22%2C%22lastName%22%3A%22McLean%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.Y.%22%2C%22lastName%22%3A%22Warren%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Brodie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Jones%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.A.%22%2C%22lastName%22%3A%22Gallagher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T.%22%2C%22lastName%22%3A%22Barrett%22%7D%5D%2C%22abstractNote%22%3A%22Hyperpolarised%20%5B1-13C%5Dpyruvate%20MRI%20%28HP-13C-MRI%29%20is%20an%20emerging%20metabolic%20imaging%20technique%20that%20has%20shown%20promise%20for%20evaluating%20prostate%20cancer%20%28PCa%29%20aggressiveness.%20Accurate%20tumour%20delineation%20on%20HP-13C-MRI%20is%20vital%20for%20quantitative%20assessment%20of%20the%20underlying%20tissue%20metabolism.%20However%2C%20there%20is%20no%20consensus%20on%20the%20optimum%20method%20for%20segmenting%20HP-13C-MRI%2C%20and%20whole-mount%20pathology%20%28WMP%29%20as%20the%20histopathological%20gold-standard%20is%20only%20available%20for%20surgical%20patients.%20Although%20proton%20MRI%20can%20be%20used%20for%20tumour%20delineation%2C%20this%20approach%20significantly%20underestimates%20tumour%20volume%2C%20and%20metabolic%20tumour%20segmentation%20based%20on%20HP-13C-MRI%20could%20provide%20an%20important%20functional%20metric%20of%20tumour%20volume.%20In%20this%20study%2C%20we%20quantified%20metabolism%20using%20HP-13C-MRI%20and%20segmentation%20approaches%20based%20on%20WMP%20maps%2C%201H-MRI-derived%20T2-weighted%20imaging%20%28T2WI%29%2C%20and%20HP-13C-MRI-derived%20total%20carbon%20signal-to-noise%20ratio%20maps%20%28TC-SNR%29%20with%20an%20SNR%20threshold%20of%205.0.%2013C-labelled%20pyruvate%20SNR%2C%20lactate%20SNR%2C%20TC-SNR%2C%20and%20the%20pyruvate-to-lactate%20exchange%20rate%20constant%20%28kPL%29%20were%20significantly%20higher%20when%20measured%20using%20the%20TC-SNR-guided%20approach%2C%20which%20also%20corresponded%20to%20a%20significantly%20higher%20tumour%20epithelial%20expression%20on%20RNAscope%20imaging%20of%20the%20enzyme%20catalysing%20pyruvate-to-lactate%20metabolism%20%28lactate%20dehydrogenase%20%28LDH%29%29.%20However%2C%20linear%20regression%20and%20Bland-Altman%20analyses%20demonstrated%20a%20strong%20linear%20relationship%20between%20all%20three%20segmentation%20approaches%2C%20which%20correlated%20significantly%20with%20RNA-scope-derived%20epithelial%20LDH%20expression.%20These%20results%20suggest%20that%20standard-of-care%20T2WI%20and%20TC-SNR%20maps%20could%20be%20used%20as%20clinical%20reference%20tools%20for%20segmenting%20localised%20PCa%20on%20HP-13C-MRI%20in%20the%20absence%20of%20the%20WMP%20gold%20standard.%20The%20TC-SNR-guided%20approach%20could%20be%20used%20clinically%20to%20target%20biopsies%20towards%20highly%20glycolytic%20tumour%20areas%20and%20therefore%20to%20sample%20aggressive%20disease%20with%20higher%20precision.%20KEY%20POINTS%3A%20%5Cu2022%20T2WI-%20and%20TC-SNR-guided%20segmentations%20can%20be%20used%20in%20all%20PCa%20patients%20and%20do%20not%20explicitly%20require%20WMP%20maps.%20%5Cu2022%20Agreement%20between%20the%20three%20segmentation%20approaches%20is%20biologically%20validated%20by%20their%20strong%20relationship%20with%20epithelial%20LDH%20mRNA%20expression.%20%5Cu2022%20The%20TC-SNR-guided%20approach%20can%20potentially%20be%20used%20to%20identify%20occult%20disease%20on%201H-MRI%20and%20target%20the%20most%20glycolytically%20active%20regions.%22%2C%22date%22%3A%222022-06-22%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00330-022-08929-7%22%2C%22ISSN%22%3A%221432-1084%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpubmed%5C%2F35731287%22%2C%22collections%22%3A%5B%224956CJHC%22%5D%2C%22dateModified%22%3A%222023-01-09T13%3A08%3A04Z%22%7D%7D%2C%7B%22key%22%3A%22HCEF48MT%22%2C%22library%22%3A%7B%22id%22%3A2789237%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kaggie%20et%20al.%22%2C%22parsedDate%22%3A%222022-05-06%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EKaggie%2C%20J.%20D.%2C%20Khan%2C%20A.%20S.%2C%20Matys%2C%20T.%2C%20Schulte%2C%20R.%20F.%2C%20Locke%2C%20M.%20J.%2C%20Grimmer%2C%20A.%2C%20Frary%2C%20A.%2C%20Menih%2C%20I.%20H.%2C%20Latimer%2C%20E.%2C%20Graves%2C%20M.%20J.%2C%20McLean%2C%20M.%20A.%2C%20%26amp%3B%20Gallagher%2C%20F.%20A.%20%282022%29.%20Deuterium%20metabolic%20imaging%20and%20hyperpolarized%2013C-MRI%20of%20the%20normal%20human%20brain%20at%20clinical%20field%20strength%20reveals%20differential%20cerebral%20metabolism.%20%3Ci%3ENeuroimage%3C%5C%2Fi%3E%2C%20%3Ci%3E257%3C%5C%2Fi%3E%2C%20119284.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.neuroimage.2022.119284%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.neuroimage.2022.119284%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Deuterium%20metabolic%20imaging%20and%20hyperpolarized%2013C-MRI%20of%20the%20normal%20human%20brain%20at%20clinical%20field%20strength%20reveals%20differential%20cerebral%20metabolism.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.D.%22%2C%22lastName%22%3A%22Kaggie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.S.%22%2C%22lastName%22%3A%22Khan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T.%22%2C%22lastName%22%3A%22Matys%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.F.%22%2C%22lastName%22%3A%22Schulte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.J.%22%2C%22lastName%22%3A%22Locke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Grimmer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Frary%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22I.H.%22%2C%22lastName%22%3A%22Menih%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Latimer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.J.%22%2C%22lastName%22%3A%22Graves%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.A.%22%2C%22lastName%22%3A%22McLean%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.A.%22%2C%22lastName%22%3A%22Gallagher%22%7D%5D%2C%22abstractNote%22%3A%22Deuterium%20metabolic%20imaging%20%28DMI%29%20and%20hyperpolarized%2013C-pyruvate%20MRI%20%2813C-HPMRI%29%20are%20two%20emerging%20methods%20for%20non-invasive%20and%20non-ionizing%20imaging%20of%20tissue%20metabolism.%20Imaging%20cerebral%20metabolism%20has%20potential%20applications%20in%20cancer%2C%20neurodegeneration%2C%20multiple%20sclerosis%2C%20traumatic%20brain%20injury%2C%20stroke%2C%20and%20inborn%20errors%20of%20metabolism.%20Here%20we%20directly%20compare%20these%20two%20non-invasive%20methods%20at%203%20T%20for%20the%20first%20time%20in%20humans%20and%20show%20how%20they%20simultaneously%20probe%20both%20oxidative%20and%20non-oxidative%20metabolism.%20DMI%20was%20undertaken%201-2%5Cu00a0h%20after%20oral%20administration%20of%20%5B6%2C6%27-2H2%5Dglucose%2C%20and%2013C-MRI%20was%20performed%20immediately%20following%20intravenous%20injection%20of%20hyperpolarized%20%5B1-13C%5Dpyruvate%20in%20ten%20and%20nine%20normal%20volunteers%20within%20each%20arm%20respectively.%20DMI%20was%20used%20to%20generate%20maps%20of%20deuterium-labelled%20water%2C%20glucose%2C%20lactate%2C%20and%20glutamate%5C%2Fglutamine%20%28Glx%29%20and%20the%20spectral%20separation%20demonstrated%20that%20DMI%20is%20feasible%20at%203%20T.%2013C-HPMRI%20generated%20maps%20of%20hyperpolarized%20carbon-13%20labelled%20pyruvate%2C%20lactate%2C%20and%20bicarbonate.%20The%20ratio%20of%2013C-lactate%5C%2F13C-bicarbonate%20%28mean%203.7%5Cu00a0%5Cu00b1%5Cu00a01.2%29%20acquired%20with%2013C-HPMRI%20was%20higher%20than%20the%20equivalent%202H-lactate%5C%2F2H-Glx%20ratio%20%28mean%200.18%5Cu00a0%5Cu00b1%5Cu00a00.09%29%20acquired%20using%20DMI.%20These%20differences%20can%20be%20explained%20by%20the%20route%20of%20administering%20each%20probe%2C%20the%20timing%20of%20imaging%20after%20ingestion%20or%20injection%2C%20as%20well%20as%20the%20biological%20differences%20in%20cerebral%20uptake%20and%20cellular%20physiology%20between%20the%20two%20molecules.%20The%20results%20demonstrate%20these%20two%20metabolic%20imaging%20methods%20provide%20different%20yet%20complementary%20readouts%20of%20oxidative%20and%20reductive%20metabolism%20within%20a%20clinically%20feasible%20timescale.%20Furthermore%2C%20as%20DMI%20was%20undertaken%20at%20a%20clinical%20field%20strength%20within%20a%20ten-minute%20scan%20time%2C%20it%20demonstrates%20its%20potential%20as%20a%20routine%20clinical%20tool%20in%20the%20future.%22%2C%22date%22%3A%222022-05-06%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.neuroimage.2022.119284%22%2C%22ISSN%22%3A%221095-9572%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpubmed%5C%2F35533826%22%2C%22collections%22%3A%5B%224956CJHC%22%5D%2C%22dateModified%22%3A%222022-09-12T12%3A46%3A03Z%22%7D%7D%5D%7D
Woitek, R., McLean, M. A., Ursprung, S., Rueda, O. M., Manzano Garcia, R., Locke, M. J., Beer, L., Baxter, G., Rundo, L., Provenzano, E., Kaggie, J., Patterson, A., Frary, A., Field-Rayner, J., Papalouka, V., Kane, J., Benjamin, A. J. V., Gill, A. B., Priest, A. N., … Gallagher, F. A. (2023). Supplementary Materials from Hyperpolarized Carbon-13 MRI for Early Response Assessment of Neoadjuvant Chemotherapy in Breast Cancer Patients. American Association for Cancer Research (AACR). https://doi.org/10.1158/0008-5472.22561915
Woitek, R., McLean, M. A., Ursprung, S., Rueda, O. M., Manzano Garcia, R., Locke, M. J., Beer, L., Baxter, G., Rundo, L., Provenzano, E., Kaggie, J., Patterson, A., Frary, A., Field-Rayner, J., Papalouka, V., Kane, J., Benjamin, A. J. V., Gill, A. B., Priest, A. N., … Gallagher, F. A. (2023). Data from Hyperpolarized Carbon-13 MRI for Early Response Assessment of Neoadjuvant Chemotherapy in Breast Cancer Patients. American Association for Cancer Research (AACR). https://doi.org/10.1158/0008-5472.c.6565186
Zaccagna, F., McLean, M. A., Grist, J. T., Kaggie, J., Mair, R., Riemer, F., Woitek, R., Gill, A. B., Deen, S., Daniels, C. J., Ursprung, S., Schulte, R. F., Allinson, K., Chhabra, A., Laurent, M.-C., Locke, M., Frary, A., Hilborne, S., Patterson, I., … Gallagher, F. A. (2022). Imaging Glioblastoma Metabolism by Using Hyperpolarized [1-13C]Pyruvate Demonstrates Heterogeneity in Lactate Labeling: A Proof of Principle Study. Radiol Imaging Cancer, 4(4), e210076. https://doi.org/10.1148/rycan.210076
Sushentsev, N., McLean, M. A., Warren, A. Y., Brodie, C., Jones, J., Gallagher, F. A., & Barrett, T. (2022). The potential of hyperpolarised 13C-MRI to target glycolytic tumour core in prostate cancer. Eur Radiol. https://doi.org/10.1007/s00330-022-08929-7
Kaggie, J. D., Khan, A. S., Matys, T., Schulte, R. F., Locke, M. J., Grimmer, A., Frary, A., Menih, I. H., Latimer, E., Graves, M. J., McLean, M. A., & Gallagher, F. A. (2022). Deuterium metabolic imaging and hyperpolarized 13C-MRI of the normal human brain at clinical field strength reveals differential cerebral metabolism. Neuroimage, 257, 119284. https://doi.org/10.1016/j.neuroimage.2022.119284
