Research Associate

Research Associate/Physicist: Department of Radiology, University of Cambridge

Clinical Scientist (Physics): MRIS, Imaging Department, Cambridge University Hospitals NHS Foundation Trust

Specialities: Magnetic resonance imaging and computational image analysis

Email: Andrew Gill Tel.: +44 (0)1223 746441

Profile

Andrew Gill graduated in Natural Sciences and Computer Science in 1993 from the University of Cambridge. After working for several years in the commercial sector as a software engineer he retrained as a Clinical Scientist at Cambridge University Hospitals from 2006-10 whilst studying for a M.Sc. in Radiation Physics at University College London. His Ph.D. studies were subsequently undertaken part-time at the University of Cambridge and involved the analysis of dynamic contrast-enhanced MR images using pharmacokinetic (PK) modelling. This work looked in particular at biomarkers of treatment response in tumours, temporal resolution requirements for successful PK model application and the repeatability of PK model analyses.

In 2014, he joined Dr Ferdia Gallagher’s research group as an image analyst with particular focus on hyperpolarized ¹³C imaging in cancer and sodium MR imaging. He also worked on quantifying organ distortion from image volumes and applied this to several studies in prostate cancer.

Now working in Prof Evis Sala’s Radiogenomics & Quantitative Imaging group, his current research interests include the design of software to aid habitat detection in tumours, supporting a process for MRI-tissue sample alignment using 3-D printed moulds. He has also recently written a software pipeline to facilitate the radiomic analysis of tissue image textures.

Concurrently with his work for the University of Cambridge, he provides research MR physics support to Royal Papworth Hospital NHS Foundation Trust, specialising in thoracic image analysis. He is currently setting up hyperpolarized Xenon lung imaging studies at Royal Papworth in collaboration with Prof Jim Wild (University of Sheffield), as well analysing data from dynamic contrast enhanced MR studies in mesothelioma patients.

Current research interests

MR and CT image analysis; radiomics/radiogenomics; DCE-MRI kinetic model analysis; imaging biomarkers; organ distortion

Professional Education and Training

HCPC registration as Clinical Scientist: 2010

Selected publications

Gallagher, F. A., Woitek, R., McLean, M. A., Gill, A. B.*, Manzano Garcia, R., Provenzano, E., . . . Brindle, K. M. (2020). Imaging breast cancer using hyperpolarized carbon-13 MRI.. Proc Natl Acad Sci U S A, 117(4), 2092-2098. doi:10.1073/pnas.1913841117

Gill, A. B.*, Czarniecki, M., Gallagher, F. A., & Barrett, T. (2017). A method for mapping and quantifying whole organ diffusion-weighted image distortion in MR imaging of the prostate.. Sci Rep, 7(1), 12727. doi:10.1038/s41598-017-13097-6

Gill, A. B.*, Hilliard, N. J., Hilliard, S. T., Graves, M. J., Lomas, D. J., & Shaw, A. (2017). A semi-automatic method for the extraction of the portal venous input function in quantitative dynamic contrast-enhanced CT of the liver.. Br J Radiol, 90(1075), 20160875. doi:10.1259/bjr.20160875

Gill, A. B.*, Anandappa, G., Patterson, A. J., Priest, A. N., Graves, M. J., Janowitz, T., . . . Lomas, D. J. (2015). The use of error-category mapping in pharmacokinetic model analysis of dynamic contrast-enhanced MRI data.. Magn Reson Imaging, 33(2), 246-251. doi:10.1016/j.mri.2014.10.010

Gill, A. B.*, Black, R. T., Bowden, D. J., Priest, A. N., Graves, M. J., & Lomas, D. J. (2014). An investigation into the effects of temporal resolution on hepatic dynamic contrast-enhanced MRI in volunteers and in patients with hepatocellular carcinoma.. Phys Med Biol, 59(12), 3187-3200. doi:10.1088/0031-9155/59/12/3187

Sala, E., Kataoka, M. Y., Priest, A. N., Gill, A. B.*, McLean, M. A., Joubert, I., . . . Brenton, J. D. (2012). Advanced ovarian cancer: multiparametric MR imaging demonstrates response- and metastasis-specific effects.. Radiology, 263(1), 149-159. doi:10.1148/radiol.11110175

Barrett, T., Gill, A. B.*, Kataoka, M. Y., Priest, A. N., Joubert, I., McLean, M. A., . . . Sala, E. (2012). DCE and DW MRI in monitoring response to androgen deprivation therapy in patients with prostate cancer: a feasibility study.. Magn Reson Med, 67(3), 778-785. doi:10.1002/mrm.23062