CRUK Senior Cancer Research Fellow
Reader in Molecular Imaging
Honorary Consultant Radiologist
Department of Radiology, University of Cambridge, Addenbrooke’s Hospital
Speciality: Oncological and Molecular Imaging, MRI, PET.
Contact: Email: FA Gallagher Tel.: + 44 (0)1223 746438
Professor Ferdia Gallagher is an academic radiologist and CRUK-funded Senior Research Fellow who leads the Clinical Molecular Imaging Group in the Department of Radiology. His laboratory develops new functional and molecular imaging methods to detect cancer and early response to therapy, with the aim of translating these techniques into humans.
His team is particularly interested in methods to probe cancer metabolism non-invasively and he leads the clinical hyperpolarised carbon-13 MRI programme in Cambridge. Hyperpolarised MRI is an emerging method to non-invasively assess tissue metabolism using pyruvate as a probe to visualise tumour lactate formation and we are currently studying this technique in a number of human tumours. We have established a bespoke pharmacy facility on site to enable this and are developing new molecules for use in patients. The group is also interested in the application of proton spectroscopy to study tumour metabolism, as well as other multinuclear and multimodality approaches such as sodium MRI and PET/CT. We are applying these methods to monitor treatment response in a range of settings, including the use of immunotherapy. We are also studying novel cell labelling approaches to complement more conventional approaches to monitor immune infiltration into tumours.
Professor Gallagher studied medicine at both the Universities of Cambridge and Oxford before training as a radiologist at Addenbrooke’s Hospital. He undertook a PhD in Biochemistry in Cambridge as part of a CRUK Clinical Research Training Fellowship. He has previously been awarded both a Clinician Scientist and an Advanced Clinician Scientist Fellowship from CRUK. He is currently a University Reader in Molecular imaging and an Honorary Consultant Radiologist.
Professor Gallagher sits on a number of international committees and is currently Chair of the Research Committee of the European Society for Hybrid Medical Imaging, Board member of the European Society of Radiology Research Committee and Past Chair of the MR of the Cancer Study Group of the International Society of Magnetic Resonance in Medicine (ISMRM). He has received Outstanding Teacher awards from ISMRM in 2012 and 2016. Nationally, he sits on the CRUK New Investigator Committee and Academy of Royal Colleges Genomics Champion Group. He is a Fellow of Gonville and Caius College.
|Degree||Awarding Institution||Field of Study||Graduated|
|University of Cambridge
University of Oxford
|FRCR||Royal College of Radiologists||Radiology||2005|
|PhD||University of Cambridge||Biochemistry||2010|
|FRCP||Royal College of Physicians||Medicine||2018|
Oncological Imaging, Molecular Imaging, Hyperpolarised 13C, Magnetic Resonance Imaging, Positron Emission Tomography
Gallagher group members:
Hyperpolariser pharmacy team:
2019: Doreen Lau, Women in Molecular Imaging Network Scholar Award.
2019: Fulvio Zaccagna, Guarantor of Brain Award.
2018: Doreen Lau, William Negendank Young Investigator Award, first prize. International Society of Magnetic Resonance in Medicine (ISMRM) MR of Cancer Study Group, Dublin.
2018: Fulvio Zaccagna, William Negendank Young Investigator Award, third prize. ISMRM MR of Cancer Study Group, Dublin.
2018: Laura Lechermann, Scholarship to attend the Summer School on Translational Cancer Research, Portugal.
2018: James Grist, Magna Cum Laude, ISMRM, Paris 2018.
2017: Ruth Casey, Best Oral Presentation, Irish Endocrine Society, Dublin.
2017: James Grist, Best Presentation Prize, British Chapter of ISMSM, Liverpool.
2017: Ahmed Maiter, European Congress of Radiology best medical student presentation (neuroradiology).
2016: Ahmed Maiter, Glasgow Neurological Conference Best Poster Presentation Prize.
2016: Fulvio Zaccagna, Future researcher award by the Royal Academy of Engineering 2016.
2016: Ahmed Maiter, Royal College of Radiologists Clinical Oncology undergraduate prize for a research project.
2015: Charlie Daniels, third place at the British Chapter postgraduate meeting of ISMRM.
Quantifying normal human brain metabolism using hyperpolarized [1-13C]pyruvate and magnetic resonance imaging.
Grist JT, McLean MA, Riemer F, Schulte RF, Deen SS, Zaccagna F, Woitek R, Daniels CJ, Kaggie JD, Matys T, Patterson I, Slough R, Gill AB, Chhabra A, Eichenberger R, Laurent MC, Comment A, Gillard JH, Coles AJ, Tyler DJ, Wilkinson I, Basu B, Lomas DJ, Graves MJ, Brindle KM, Gallagher FA.
Neuroimage. 2019 Apr 1;189:171-179.
Quantification of total and intracellular sodium concentration in primary prostate cancer and adjacent normal prostate tissue with magnetic resonance imaging.
Barrett T, Riemer F, McLean M, Kaggie J, Robb F, Tropp J, Warren A, Bratt O, Shah N, Gnanapragasam V, Gilbert F, Graves M, Gallagher FA.
Invest Radiol. 2018 Aug;53(8):450-456.
Translating in vivo metabolomic analysis of succinate dehydrogenase deficient tumours into clinical utility.
Casey RT, McLean MA, Madhu B, Challis BG, Ten Hoopen R, Roberts T, Clark GR, Pittfield D, Simpson HL, Bulusu VR, Allinson K, Happerfield L, Park SM, Marker A, Giger O, Maher ER, Gallagher FA.
JCO Precis Oncol. 2018 Mar 29;2:1-12
Prospective study evaluating the relative sensitivity of 18F-NaF PET/CT for detecting skeletal metastases from renal cell carcinoma in comparison to multidetector CT and 99mTc-MDP bone scintigraphy, using an adaptive trial design.
Gerety EL, Lawrence EM, Wason J, Yan H, Hilborne S, Buscombe J, Cheow HK, A. S. Shaw AS, Bird N, Fife K, Heard S, Lomas DJ, Matakidou A, Soloviev D, Eisen T, Gallagher FA.
Ann of Oncol. 2015 Oct;26(10):2113-8.
Production of hyperpolarized [1,4-13C2]malate from [1,4-13C2]fumarate is a marker of cell necrosis and treatment response in tumors.
Gallagher FA, Kettunen MI, Hu DE, Jensen PR, in ‘t Zandt R, Karlsson M, Gisselsson A, Nelson SK, Witney TH, Bohndiek SE, Hansson G, Pietersen T, Lerche MH, Brindle KM.
Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19801-19806.
Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate.
Gallagher FA, Kettunen MI, Day SE, Hu DE, Ardenkjaer-Larsen JH, Zandt R, Jensen PR, Karlsson M, Golman K, Lerche MH, Brindle KM.
Nature. 2008 Jun 12;453(7197):940-3.