Department of Radiology Key People on this Project: Dr Fulvio Zaccagna, Dr Oshaani Abeyakoon, Dr Fiona Gilbert, Dr Ferdia Gallagher, Dr Tomasz Matys, Prof. Jonathan Gillard, Stephen Price, Martin Graves, Frank Riemer
The CRUK and EPSRC Cancer Imaging Centre in Cambridge and Manchester is a combined effort between the universities of Cambridge and Manchester to develop non-invasive imaging techniques to improve the diagnosis, monitoring and treatment of patients with cancer.
Images Courtesy of Dr Frank Riemer.
Figure 1: Maximum intensity projection (MIP) image of a 23Na-MRI dataset of a healthy volunteer, highlighting regional concentration differences between tissue and the ventricular system and vitreous humour. Two tubes with known sodium concentrations can be seen left and right to the temples of the volunteer containing 40 and 80 mM NaCl in 4% agar. These tubes can be used to translate image intensities into total tissue sodium concentration maps.
Figure 2: 23Na-MRI (left) and post gadolinium contrast 1H T1-weighted axial images of a patient suffering from a glioblastoma. Total tissue sodium was found to be 88.9 ± 4.8 mM in the gadolinium-enhancing part and 131.5 ± 7.1 mM in the central non-enhancing region. In comparison, the average sodium concentration of normal-appearing white matter was 39.4 ± 1.8 mM and 57.8 ± 1.3 mM in the normal-appearing grey matter.
Figure 3: Fused multi-planar reconstruction of a 1H T1-weighted post-contrast image in greyscale with co-registered 23Na-MR images overlaid in red of a patient suffering from a glioblastoma.
Figure 4: False colour apparent diffusion coefficient axial map of a healthy volunteer (left, units in mm2/s) and axial diffusional kurtosis map of the same slice (right, arbitrary units). Diffusional kurtosis is a measure that highlights deviation from Gaussian (free water) diffusion and can be used to investigate heterogeneity in tumours.