Department of Radiology, University of Cambridge, School of Clinical Medicine.
Honorary NHS SpR – Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust.
Eva Mendes Serrão, MD PhD received her medical degree from the University of Coimbra in Portugal in 2006 and then started her medical training in Clinical Radiology in Lisbon in 2008. During this period, her curiosity for science led her to volunteer in a basic research lab. In 2010 a Radiology rotation focused on magnetic resonance on pancreatic cancer at the Erasmus Hospital (Brussels, Belgium) motivated her to interrupt the medical training and pursue a career in research. She was successfully granted the Gulbenkian Champalimaud PhD fellowship for medical doctors in 2010 and subsequently a Marie Curie Fellowship in 2011 at the University of Cambridge (Cambridge, UK).
She completed her doctoral studies in 2016 at the Department of Biochemistry, University of Cambridge during which she received a number of awards for her work, and also published in several high impact peer-reviewed journals.
In 2015, she transferred her Clinical Radiology training to Cambridge under an Academic Clinical Fellow position. In 2017 she has become a Clinical Lecturer in the Department of Radiology – Addenbrooke’s Hospital (Cambridge, UK).
Her main clinical research interest is in pancreatic cancer, with particular interest in novel magnetic resonance imaging techniques as 13C-MRIS.
|Degree||Awarding Institution||Field of Study||Graduated|
|MD||Faculty of Medicine of the University of Coimbra, Portugal||Medicine||2006|
|PhD||University of Cambridge, UK||Biochemistry||2016|
Recent selected Publications
Original research papers in peer-reviewed journals:
Serrão, EM*;· Kettunen, MI; · Rodrigues, TB; Dzien, P; Wright, AJ; Gopinathan, A; Gallagher, FA; Lewis, DY; Frese, KK; Almeida, J; Howat, WJ; Tuveson, DA; Brindle, KM. MRI with hyperpolarised [1-13 C]pyruvate detects advanced pancreatic preneoplasia prior to invasive disease in a mouse model. Gut. 2016; 65:465-75 – Editor’s selection and introduction
Rodrigues, TB; Serrão, EM*.; Kennedy, BWC; Hu, D; Kettunen, MI; Brindle, Magnetic resonance imaging of tumor glycolysis using hyperpolarized 13C-labeled glucose, Nat Med. 2014;20:93-7.
Serrão, EM*;· Kettunen, MI; Rodrigues, TB; Lewis, DY; Gallagher, FA; Hu, DE; Brindle, KM. Analysis of 13 C and 14 C labeling in pyruvate and lactate in tumor and blood of lymphoma-bearing mice injected with 13 C- and 14 C-labeled pyruvate. NMR Biomed. 2018; (Epub ahead of print)
Serrão, EM*;· Rodrigues, TB; Gallagher, FA; Kettunen, MI; Kennedy, BW; Vowler, S; Burling, KA; · Brindle, KM. Effects of fasting on serial measurements of tumor metabolism using hyperpolarized 1-13C] pyruvate. NMR Biomed. 2016;29:1048-55.
Dzien, P; Tee, SS; Kettunen, MI; Lyons, SK; Larkin, TJ; Timm, KN; Hu, DE; Wright, A; Rodrigues, TB; Serrão, EM*; Marco-Rius, I; Mannion, E; D’Santos, P; Kennedy, BW; Brindle, KM. 13C magnetic resonance spectroscopy measurements with hyperpolarized [1-13C] pyruvate can be used to detect the expression of transgenic pyruvate decarboxylase activity in vivo, Magn Reson Med. 2016;76:391-401.
Gaziev, G; Wadhwa, K; Barrett, T; Koo, B; Gallagher, F; Serrão, E*; Frey, J; Seidenader, J; Echeverria, LE; Warren, A; Gnanapragasam, V; Doble, A; Kastner, C; Defining the Learning Curve for multi-parametric MRI of the prostate using MRI-TRUS fusion guided transperineal prostate biopsies as a validation tool BJU Int. 2016;117:80-6.
Serrão, EM*; Barrett, T; Wadhwa, K; Koo, B; Frey, J; Kastner, C; Gallagher, F; Investigating the ability of multiparametric MRI toexclude significant prostate cancer prior to transperineal biopsy. Can Urol Assoc J. 2015; 9:11-12.
Selected review articles:
Serrão, EM*; Brindle, KM. “Dynamic nuclear polarisation: The future of imaging in oncology?”; Porto Biomedical Journal, 2017 February
Serrão, EM*; Brindle, KM. Potential Clinical Roles for Metabolic Imaging with Hyperpolarized [1-13C]Pyruvate; Frontiers in Oncology 2016: 6 Supplement 2